Antioxidant conjugated metal complexes and their medicinal applications

Antioxidants are naturally available and man-made substances have the ability to protect cells from damage due to a number of intracellular redox activities. Moreover, Antioxidants such as α-lipoic acid, curcumin and catechin are good anticancer agents. In recent years, the usage of metal complexes as therapeutic agents is gaining importance due to their useful biological properties. Most of the metal ions act as the essential components in building drug molecules that serve as medicines for cancer and neurodegenerative diseases. In particular, metals like copper, gold, ruthenium, and platinum have adequate anticancer properties at both micro- and nano-levels. Hence, conjugation of antioxidants with metals and metal-based compounds results in hybrid bioactive materials with improved anticancer properties. In this chapter, medicinal applications of antioxidant conjugated metal complexes are reviewed and discussed.