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Updated: Aug 12, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Appreciating the potential for GPCR crosstalk with ion channels

Amy Davies1, Alejandra Tomas1

  • 1Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.

Progress in Molecular Biology and Translational Science
|January 27, 2023
PubMed
Summary

G protein-coupled receptors (GPCRs) and ion channels interact, influencing cell signaling and disease. Understanding this crosstalk offers new therapeutic strategies by co-targeting these crucial protein families.

Keywords:
CrosstalkFunctional selectivityGPCRIon channel

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