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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Related Experiment Video

Updated: Aug 12, 2025

Strategies for Assessing Autistic-Like Behaviors in Mice

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Gene×environment interactions in autism spectrum disorders.

Kimberly Keil-Stietz¹, Pamela J Lein²

¹Department of Comparative Biosciences, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, United States.

Current Topics in Developmental Biology

|January 27, 2023

Summary

Environmental chemicals may increase autism risk by interacting with genetic factors. Research aims to identify these gene-environment interactions to develop targeted interventions for autism spectrum disorder.

Keywords:

Autism Environmental risk factors Gene×environment interactions Neurodevelopmental disorders PCBs Polychlorinated biphenyls Synaptic connectivity

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Area of Science:

Environmental health
Neurodevelopmental disorders
Genetics

Background:

Environmental factors are recognized contributors to autism spectrum disorder (ASD) risk and severity.
The complex interplay between environmental chemicals and genetic predispositions in ASD etiology remains challenging to fully elucidate.
Understanding gene-environment (G×E) interactions is crucial for deciphering ASD pathophysiology.

Conclusions:

Identifying specific environmental factors and G×E interactions is key to understanding ASD.
Further research is needed to develop effective screening tools and interventions for ASD.
Mitigating the impact of ASD requires a comprehensive approach addressing both environmental and genetic influences.