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Chemical stability and physical compatibility of meropenem in admixtures for continuous and extended intravenous

Sara Giménez-Giner1, Antoni Llopis-Alemany1, Begoña Porta-Oltra1

  • 1Department of Pharmacy, Doctor Peset University Hospital, Valencia, Spain.

Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|January 27, 2023
PubMed
Abstract

Insights

Meropenem stability is maintained for prolonged infusions in critical care when refrigerated. Anticipated preparation in infusion bags is feasible for up to 24 hours, ensuring drug efficacy.

Area of Science:

  • Pharmacology
  • Critical Care Medicine
  • Pharmaceutical Chemistry

Background:

  • Prolonged intravenous beta-lactam infusions improve clinical cure rates in critical or septic patients.
  • Evaluating meropenem stability is crucial for optimizing its administration in clinical practice.
  • Assessing stability under various conditions informs the possibility of pre-prepared admixtures.

Purpose of the Study:

  • To determine the chemical stability and physical compatibility of meropenem admixtures.
  • To evaluate meropenem stability under conditions simulating clinical administration.
  • To assess the feasibility of anticipated preparation of meropenem infusions.

Main Methods:

  • Meropenem admixtures (6g or 1-2g) in 0.9% sodium chloride (NS) were prepared in infusors and infusion bags.
  • Tested at various temperatures (4.5°C, 32°C, 24.5°C) and infusion rates (2mL/h, 10mL/h).
  • Chemical stability assessed via HPLC; physical compatibility by pH and visual inspection.

Main Results:

  • Meropenem stability in infusors decreased with higher concentrations and temperatures.
  • Admixtures in infusion bags demonstrated stability and compatibility for at least 24 hours.
  • Refrigeration at 4.5°C is essential for maintaining stability in high-concentration infusor admixtures.

Conclusions:

  • Meropenem 6g in 24h infusion at 10mL/h is feasible at 4.5°C in infusors.
  • Extended infusions (3-4h) of 1-2g meropenem in infusion bags are viable.
  • Anticipated preparation of meropenem admixtures in infusion bags is possible with 24-hour stability.
Keywords:
CompatibilidadCompatibilityEstabilidadInfusorMeropenemStability

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