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Associated factors for prenatally diagnosed fetal congenital heart diseases

Yanping Ruan1,2, Zan Xie3, Xiaowei Liu1,2

  • 1Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, Beijing, China.

BMC Cardiovascular Disorders
|January 28, 2023
PubMed

Insights

Maternal history of spontaneous abortion, early pregnancy infections, stress, single umbilical artery, and paternal smoking increase the risk of fetal congenital heart disease (CHD). Targeted prenatal counseling is crucial for high-risk pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatric Cardiology
  • Public Health

Background:

  • Congenital heart diseases (CHDs) are a significant concern in fetal development.
  • Limited data exists on associated factors for prenatally diagnosed CHDs in China.
  • Understanding these factors is crucial for early detection and intervention.

Purpose of the Study:

  • To identify associated risk factors for prenatally diagnosed fetal CHDs in a large Chinese cohort.
  • To provide data for targeted prenatal care and counseling.

Main Methods:

  • A cohort of 5024 pregnant women undergoing fetal echocardiography was recruited.
  • Maternal sociodemographic, lifestyle, and fetal factors were collected.
  • Forward stepwise logistic regression analysis was employed to determine risk factors.

Main Results:

  • 875 out of 5024 fetuses were diagnosed with CHD.
  • Critical CHDs comprised 27% of cases, with Tetralogy of Fallot being most common.
  • Significant risk factors included history of spontaneous abortion, early pregnancy infections/stress, single umbilical artery, and paternal smoking.

Conclusions:

  • Several maternal and fetal factors are significantly associated with an increased risk of fetal CHD.
  • Strengthening healthcare and prenatal counseling for women with identified risk factors is recommended.
  • These findings contribute valuable epidemiological data for China.
Abstract

Keywords:
Congenital heart diseasesFactorFetalOdd ratio

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