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Updated: Jul 12, 2026
14:26
Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
Published on: April 4, 2016
TeCD: The eccDNA Collection Database for extrachromosomal circular DNA
Jing Guo1,2,3,4, Ze Zhang1,2,5, Qingcui Li5
1Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310013, China.
BMC Genomics
|January 28, 2023
Summary
Researchers developed The eccDNA Collection Database (TeCD), a new platform for accessing and analyzing extrachromosomal circular DNA (eccDNA) data. This resource aids in understanding eccDNA
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- Extrachromosomal circular DNA (eccDNA) is prevalent in eukaryotic cells.
- eccDNA is increasingly recognized for its role in tumors and aging.
- eccDNA is a significant area of modern biological research.
Purpose of the Study:
- To create a centralized database for eccDNA data.
- To provide a retrieval platform for researchers studying eccDNA.
- To facilitate the analysis of eccDNA functions.
Main Methods:
- Compiled eccDNA data from animals, plants, and fungi.
- Standardized data format and classified by species and chromosome.
- Integrated Basic Local Alignment Search Tool (BLAST) for sequence analysis.
Main Results:
- Developed The eccDNA Collection Database (TeCD).
- Stored comprehensive eccDNA information including sequence, genomic elements, and experimental data.
- Enabled sequence alignment for potential eccDNA identification.
Conclusions:
- TeCD serves as a valuable resource for eccDNA data retrieval and analysis.
- The database supports further investigation into the biological significance of eccDNA.
- Findings provide a foundation for future eccDNA research.
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