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Related Concept Videos

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Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
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Related Experiment Video

Updated: Aug 12, 2025

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
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Chronic stress in solid tumor development: from mechanisms to interventions.

Jiajing Yan1, Yibing Chen2, Minhua Luo1

  • 1MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.

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Chronic stress disrupts hormones via the neuroendocrine system, impacting cancer progression and treatment. This review explores stress

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Area of Science:

  • Neuroendocrinology
  • Oncology
  • Stress Physiology

Background:

  • Chronic stress dysregulates the neuroendocrine system, affecting hormone levels.
  • Cancer patients frequently experience stress, anxiety, and restlessness, complicating disease management.
  • Neuroendocrine activation by stress influences tumor cells and the surrounding microenvironment.

Purpose of the Study:

  • To review mechanisms linking chronic stress to the tumor microenvironment.
  • To summarize current therapeutic strategies for chronic stress in cancer patients.

Main Methods:

  • Literature review of studies on chronic stress, neuroendocrine system, and cancer.
  • Analysis of signaling pathways and cellular processes affected by stress hormones.
  • Evaluation of clinical evidence and treatment approaches.

Main Results:

  • Stress hormones promote tumor cell stemness, metastasis, angiogenesis, DNA damage, and apoptosis resistance.
  • Chronic stress induces metabolic reprogramming and immune escape in the tumor microenvironment.
  • Peritumor neuromodulation is a key mechanism of stress impact on cancer.

Conclusions:

  • Chronic stress significantly alters the tumor microenvironment through multiple pathways.
  • Effective clinical treatments for chronic stress in cancer patients are lacking.
  • Pharmacological and non-pharmacological interventions offer potential therapeutic directions.