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Related Experiment Video

Updated: Aug 12, 2025

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
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Fatigue in nurses and medication administration errors: A scoping review.

Tracey Bell1, Madeline Sprajcer2, Tracey Flenady1

  • 1School of Nursing, Midwifery and Social Sciences, Central Queensland University, Rockhampton, Queensland, Australia.

Journal of Clinical Nursing
|January 28, 2023
PubMed
Summary

Nurse fatigue significantly contributes to medication administration errors (MAEs) and near misses in hospitals. Addressing nurse fatigue through policy changes and management systems is crucial for patient safety.

Keywords:
fatiguemedication administration errorsnear missesnurseshift worksleepsleep deprivationsleep disorders

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Area of Science:

  • Nursing Science
  • Patient Safety Research
  • Healthcare Management

Background:

  • Medication administration errors (MAEs) result in preventable patient harm and substantial healthcare costs.
  • Nurse fatigue is an emerging and significant factor contributing to MAEs.
  • Understanding fatigue's impact on medication administration is vital due to its frequency as a nursing task.

Purpose of the Study:

  • To systematically review the existing evidence on the effect of nurse fatigue on medication administration errors and near misses.
  • Focus on registered nurses working within hospital environments.

Main Methods:

  • A scoping review guided by the Arksey and O'Malley framework.
  • Data extraction and analysis using the PAGER framework.
  • Searched four databases (CINAHL, PubMed, Scopus, PsycINFO) for peer-reviewed English articles without date restrictions, focusing on nurses, MAEs, and fatigue/work hours.

Main Results:

  • Eighty-two percent of the 38 included studies identified fatigue as a factor in MAEs and near misses.
  • Fatigue is linked to diminished cognitive function, attention, vigilance, and overall nursing performance, impacting patient safety.
  • Shift work components like circadian rhythm disruption and overtime were identified as contributors, though fatigue measurement methods varied significantly.

Conclusions:

  • Nurse fatigue, influenced by factors like night shifts and overtime, negatively affects performance in medication administration.
  • The heterogeneity in findings suggests a need for larger studies, particularly on overtime's impact.
  • Re-evaluation of safe working hour policies and implementation of fatigue management systems are recommended for safe patient care.