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Association of handgrip strength and/or walking pace with incident chronic kidney disease: A UK biobank observational

Panpan He1,2,3,4, Ziliang Ye1,2,3,4, Mengyi Liu1,2,3,4

  • 1Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Journal of Cachexia, Sarcopenia and Muscle
|January 28, 2023
PubMed

Insights

Higher handgrip strength and faster walking pace are linked to a lower risk of developing chronic kidney disease (CKD). These physical indicators show a significant inverse relationship with incident CKD in the general population.

Area of Science:

  • Gerontology
  • Nephrology
  • Epidemiology

Background:

  • Uncertainty exists regarding the individual and combined effects of handgrip strength and walking pace on chronic kidney disease (CKD) risk.
  • Large-scale observational data from the UK Biobank were utilized to address this knowledge gap.

Purpose of the Study:

  • To investigate the relationship between handgrip strength and/or walking pace and the incidence of CKD.
  • To determine if these physical parameters serve as predictive markers for CKD development.

Main Methods:

  • Analysis of data from 417,504 participants in the UK Biobank, free of pre-existing kidney disease.
  • Handgrip strength measured by dynamometer; walking pace self-reported (slow, average, brisk).
  • Cox proportional hazards models employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CKD.

Main Results:

  • Over a median follow-up of 12.1 years, 11,064 (2.7%) participants developed incident CKD.
  • Both higher handgrip strength and faster walking pace were significantly inversely associated with CKD risk.
  • The lowest risk of incident CKD was observed in participants with both higher handgrip strength and average or brisk walking pace.

Conclusions:

  • Handgrip strength and walking pace are significant inverse predictors of incident CKD in the general population.
  • These easily measurable physical attributes may play a role in assessing CKD risk.
Abstract

Keywords:
Chronic kidney diseaseHandgrip strengthUK biobankWalking pace

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