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Updated: Aug 12, 2025
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
What you need to know about migraine in Hughes syndrome patients
J R Schofield1,2, K L Hassell3
1Center for Multisystem Disease, Denver, CO, USA.
Background:
Headache, often migrainous, is common in patients with antiphospholipid antibodies, whether or not they meet Sydney criteria for a definite diagnosis of Hughes syndrome. Migraine may be a harbinger of stroke in this patient population and even refractory migraine may be highly responsive to antithrombotic therapy in this clinical context.
Purpose:
To summarize what is known to date about managing this important manifestation of the immune-mediated hypercoagulable Hughes syndrome.
Results:
We provide a suggested management algorithm for refractory headache in this unique patient population.
Conclusion:
Most neurologists don't see or recognize many aPL-positive patients in their practice, so hematologists and rheumatologists who see these patients should recognize that refractory headache may be a manifestation of their immune-mediated hypercoagulable disorder and understand that the potential risks of not addressing this issue may be high.
