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Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and

Mohammad Amin Momeni-Moghaddam1,2, Gholamreza Asadikaram2,3, Mohammad Masoumi4

  • 1Department of Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|January 28, 2023
PubMed

Insights

Opium addiction did not alter scavenger receptor expression in coronary artery disease (CAD) patients. However, opium use was linked to increased inflammation via tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) in CAD.

Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Immunology

Background:

  • Coronary artery disease (CAD) mechanisms are complex and not fully understood.
  • The impact of opium on CAD pathogenesis, particularly regarding inflammatory markers and scavenger receptors, requires investigation.

Purpose of the Study:

  • To investigate the effect of opium addiction on scavenger receptor expression (CD36, CD68, CD9) in monocytes.
  • To evaluate plasma levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), malondialdehyde (MDA), and nitric oxide metabolites (NOx) in CAD patients with and without opium addiction.

Main Methods:

  • Case-control study involving three groups: opium-addicted CAD patients, non-addicted CAD patients, and controls.
  • Quantitative polymerase chain reaction (RT-qPCR) and flow cytometry used to assess gene and protein expression of CD9, CD36, and CD68.
  • Plasma levels of TNF-α, IFN-γ, MDA, and NOx were measured.

Main Results:

  • Opium-addicted CAD patients showed significantly higher plasma levels of TNF-α compared to both non-addicted CAD patients and controls.
  • Malondialdehyde (MDA) levels were significantly elevated in both CAD groups versus controls.
  • No significant differences were observed in the expression of CD9, CD36, CD68, IFN-γ, or NOx across the three groups.

Conclusions:

  • Opium addiction does not appear to significantly affect the gene or protein expression of CD36, CD68, and CD9 in CAD patients.
  • Opium may contribute to CAD development through inflammatory pathways independent of these specific scavenger receptors, evidenced by elevated TNF-α.
Keywords:
CD36CD68CD9Opiumcoronary artery diseaseinflammation

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