Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosurgery01:30

Psychosurgery

91
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
91
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

18
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
18
Drug Therapy01:28

Drug Therapy

83
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
83
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

113
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
113
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

499
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
499
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

20
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serious mental illness and cancer: A call to action for equitable care.

CA: a cancer journal for clinicians·2026
Same author

Posterior Cortical Atrophy Presenting with Psychotic Delirium.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same author

Psychiatric Advance Directives: An Analysis of Current Usage at a Large County Hospital.

Psychiatric research and clinical practice·2025
Same author

Meeting the challenges of electronic health record (EHR) optimization.

NPJ digital medicine·2025
Same author

Decision-making capacity evaluation in older cancer patients: A call to action.

Palliative & supportive care·2025
Same author

Expressive writing interventions in patients with cancer: A scoping literature review.

Palliative & supportive care·2025

Related Experiment Video

Updated: Aug 12, 2025

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

13.8K

Selective Serotonin Reuptake Inhibitor (SSRI) Bleeding Risk: Considerations for the Consult-Liaison Psychiatrist.

Daniel McFarland1,2, Dale Merchant3,4, Abhisek Khandai5

  • 1Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA. danielcurtismcfarland@gmail.com.

Current Psychiatry Reports
|January 28, 2023
PubMed
Summary

Selective serotonin reuptake inhibitors (SSRIs) can increase bleeding risk, especially with other medical conditions. Consult-liaison psychiatrists must weigh these risks against benefits for optimal antidepressant management.

Keywords:
Antidepressant side effectsBleeding riskHemorrhageMedically complex patientsSerotonin reuptake inhibitorThrombocytopenia

More Related Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.2K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.1K

Related Experiment Videos

Last Updated: Aug 12, 2025

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

13.8K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.2K
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.1K

Area of Science:

  • Psychiatry
  • Pharmacology
  • Hematology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants.
  • SSRI use is associated with a potential, though often marginally elevated, risk of bleeding.
  • Concomitant medical and surgical conditions can significantly exacerbate SSRI-related bleeding risks.

Purpose of the Study:

  • To provide a clinically focused review of bleeding issues associated with SSRI use.
  • To guide consult-liaison psychiatrists in managing SSRI-related bleeding risks.
  • To integrate a hematologic perspective into antidepressant management strategies.

Main Methods:

  • Literature review focusing on SSRI-induced bleeding.
  • Analysis of how co-existing medical conditions impact bleeding risk.
  • Incorporation of mechanistic understanding where direct evidence is limited.

Main Results:

  • SSRI-related bleeding risk is often cumulative and influenced by patient-specific factors.
  • The interaction between SSRIs and other medical conditions requires careful clinical consideration.
  • Mechanistic insights can aid in managing complex cases with limited direct data.

Conclusions:

  • Consult-liaison psychiatrists play a key role in assessing and managing SSRI-related bleeding risks.
  • A collaborative approach with other medical specialties is essential for responsible antidepressant management.
  • Clinicians must balance antidepressant efficacy with potential bleeding complications in diverse patient populations.