Evaluation of quinidine Lipettes -- a sustained release preparation

A new sustained release preparation (Lipettes) of quinidine has been evaluated with regard to dissolution, absorption, serum concentration and side-effects. The serum levels of quinidine after single oral doses and after long-term treatment have been compared with the serum levels after administration of some other quinidine preparations on the Swedish market. The side-effects of the sustained release preparations have also been studied. Results indicated that this new sustained release quinidine preparation yields more even serum concentrations of quinidine and seemed to cause less troublesome side-effects than the marketed preparations.