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A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
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Mera: A scalable high throughput automated micro-physiological system.

Finola E Cliffe1, Conor Madden1, Patrick Costello1

  • 1Hooke Bio Ltd, L4A Smithstown Industrial Estate, Shannon, Co. Clare V14 XH92, Ireland.

SLAS Technology
|January 28, 2023
PubMed
Summary

A new automated system, Mera, enables scalable microtissue culture and drug testing. This system improves preclinical drug efficacy and toxicity prediction using microphysiological systems (MPS).

Keywords:
High throughput screeningMicrofluidicsPreclinical drug screening, Microphysiological systems

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Area of Science:

  • Biotechnology
  • Drug Discovery
  • Toxicology

Background:

  • Scalable microphysiological systems (MPS) are crucial for predicting drug efficacy and toxicity in preclinical stages.
  • Current MPS technologies face challenges in automation, modularity, and scalability for high-throughput screening.

Purpose of the Study:

  • To introduce Mera, an automated, modular, and scalable system for microtissue culture and assaying.
  • To demonstrate Mera's capability in drug toxicity assessment using a liver microtissue model.

Main Methods:

  • Development of Mera, featuring interconnected fluidics, environmental control, and automated image capture.
  • Utilizing a dual-mode fluidics system for microtissue maturation and drug/stain recirculation.
  • Performing Acetaminophen-induced toxicity assays on HepG2 liver microtissues with viability staining.

Main Results:

  • Successful demonstration of Mera's automated image capture and microtissue assay functionality.
  • Viability and toxicity assays were validated in both 3x3 and 4x10 well formats.
  • The system effectively cultured and assayed liver microtissues for toxicity.

Conclusions:

  • Mera provides a viable foundation for scalable microtissue culture and assay development.
  • The automated system enhances the potential for reliable preclinical drug screening.
  • Mera offers a modular and adaptable platform for various microtissue applications.