Related Experiment Video

Updated: Aug 12, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

485

Risk score for coronary heart disease (CHD-RISK) and hemodynamically significant aortic valve stenosis

Odong Christopher1, Zhenyu Xiong1, Yiquan Huang1

  • 1Cardiology Department, First Affiliated Hospital of Sun Yat-Sen University, China; NHC Key Laboratory of Assisted Circulation Sun Yat-Sen University, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|January 29, 2023
PubMed

Insights

Coronary heart disease risk scores (CHD-RISK) can predict aortic stenosis (AS) risk. Higher CHD-RISK is associated with increased AS incidence, particularly in females and smokers.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Epidemiology

Background:

  • Investigating the link between coronary heart disease (CHD) risk factors and aortic stenosis (AS).
  • Limited research exists on the predictive value of CHD risk scores for AS.
  • The applicability of CHD risk scores (CHD-RISK) for forecasting AS is unclear.

Purpose of the Study:

  • To determine the association between CHD-RISK and the incidence of AS.
  • To evaluate if CHD-RISK can be utilized as a predictor for AS development.

Main Methods:

  • Analysis of 4791 participants followed from 1990-1992 to 2013.
  • CHD-RISK was calculated, and AS was identified via Doppler echocardiography.
  • Multivariate logistic regression models were employed to assess the association between CHD-RISK and AS.

Main Results:

  • A 6% increase in CHD-RISK was associated with a 1.194 odds ratio (OR) for AS (p=0.002).
  • Higher quintiles of CHD-RISK showed significantly increased AS risk, with the highest quintile (>9.21%) having an OR of 2.66 (p<0.001).
  • AS incidence was higher in females, individuals aged ≥55, current smokers, and those with BMI ≥30 kg/m².

Conclusions:

  • CHD-RISK is significantly associated with AS.
  • CHD-RISK may serve as a valuable tool for predicting AS risk, similar to its role in CHD.
  • Identifying high-risk subgroups (females, smokers, older adults, obese individuals) is crucial for targeted AS management and treatment strategies.
Abstract

Keywords:
Aortic valve stenosisCoronary heart disease risk scoreDoppler echocardiographyRisk factor

More Related Videos

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

11.8K
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

8.0K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
56
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
41
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
32
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
24
Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
22
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
29