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Haemostatic alterations in lymphomas and tumours
1First Department of Medicine, Pécs University Medical School, Hungary.
Acta Medica Hungarica
|January 1, 1987
Summary
Blood clotting abnormalities are common in cancer patients, with hypercoagulability more pronounced in solid tumors. Platelet function is often impaired in non-Hodgkin lymphomas, indicating widespread coagulation system activation.
Area of Science:
- Hematology
- Oncology
- Thrombosis
Background:
- Blood coagulation disturbances frequently occur in malignancies.
- Deep vein thrombosis and pulmonary embolism can precede solid tumor diagnosis.
- Chemotherapy, irradiation, surgery, and infections trigger clotting abnormalities.
Purpose of the Study:
- To investigate plasmatic clotting factors and platelet functions in patients with solid tumors and lymphoma.
- To identify characteristic hemostatic changes associated with different cancer types.
Main Methods:
- Analysis of plasmatic clotting factors.
- Assessment of platelet functions.
- Evaluation of ethanol positivity and euglobulin lysis.
Main Results:
- Characteristic findings included ethanol positivity, elevated fibrinogen, reduced euglobulin lysis, and impaired platelet function.
- Hypercoagulability signs were more pronounced in solid tumors.
- Platelet functions were decreased in non-Hodgkin lymphomas.
Conclusions:
- The study confirms activation of blood clotting and platelets in both solid tumors and lymphomas.
- These findings correlate with existing literature on cancer-associated thrombosis.