Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chiral emission from chirotopic nanostructures.

Nature communications·2026
Same author

Theranostic Nanoparticles for Fluorosensitive Visualization and Inhibition of Amyloid Beta-Induced Neuroinflammation.

Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems·2026
Same author

Reefense: Living shoreline mosaics can achieve ecological and engineering outcomes with interdisciplinary design.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Temporal-spatial distribution characteristics and associated socioeconomic factors of medical expenditures for rural patients with chronic kidney disease in Fujian Province, Southeast China.

International journal of health geographics·2026
Same author

Review of shortwave infrared imaging and spectroscopy in tissue [Invited].

Biomedical optics express·2025
Same author

Alternating current pre-treatment enhances multi-enzymatic activity of high-entropy alloy nanozymes that regulate metabolism for effective tumor immunotherapy.

Nature communications·2025

Related Experiment Video

Updated: Aug 12, 2025

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.3K

Short-Wave Infrared Emitting Nanocomposites for Fluorescence-Guided Surgery.

Carolina Bobadilla Mendez1, Amber Gonda1, Jay V Shah1

  • 1Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 USA.

IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-Optics Society
|January 30, 2023
PubMed
Summary

Rare-earth-doped albumin-encapsulated nanocomposites (REANCs) show superior tumor visualization in fluorescence-guided surgery (FGS). REANCs offer higher signal-to-background ratios and better tissue contrast than indocyanine green (ICG).

Keywords:
Biomedical optical imagingbiomedical infrared imagingfluorescencenanotechnologysurgery

More Related Videos

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

1.9K
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.4K

Related Experiment Videos

Last Updated: Aug 12, 2025

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.3K
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

1.9K
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.4K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Surgical Imaging

Background:

  • Fluorescence-guided surgery (FGS) utilizes exogenous probes for real-time tissue visualization.
  • Current contrast agents like indocyanine green (ICG) have limitations in certain applications.
  • Short-wave infrared (SWIR) probes offer potential for enhanced tissue penetration and signal detection.

Purpose of the Study:

  • To investigate rare-earth-doped albumin-encapsulated nanocomposites (REANCs) as SWIR contrast agents for FGS.
  • To compare the efficacy of REANCs against clinically used ICG in an animal cancer model.
  • To evaluate the photostability and performance of REANCs under ambient lighting conditions.

Main Methods:

  • Development and characterization of REANCs as SWIR emitting agents.
  • Intratumoral administration of REANCs and ICG in a 4T1 breast cancer mouse model.
  • Real-time fluorescence imaging during surgery and ex vivo analysis of excised tissues.
  • Quantitative assessment of signal-to-background ratio (SBR) and fluorescence intensity.

Main Results:

  • REANCs demonstrated a significantly higher SBR for tumors compared to ICG.
  • Enhanced contrast between tumor and surrounding tissues was observed with REANCs post-FGS.
  • REANCs exhibited excellent photostability over 2 hours and effective performance under ambient light.

Conclusions:

  • REANCs represent a promising class of SWIR contrast agents for FGS.
  • These nanocomposites offer improved tumor delineation and tissue contrast over ICG.
  • REANCs have potential for broader clinical translation in fluorescence-guided surgical applications.