Related Experiment Video
Updated: Aug 12, 2025
11:13
Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
Published on: November 29, 2013
14.2K
Long-term memory, synaptic plasticity and dopamine in rodent medial prefrontal cortex: Role in executive functions
Denis Sheynikhovich1, Satoru Otani1, Jing Bai2
1Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
Frontiers in Behavioral Neuroscience
|January 30, 2023
Summary
This review explores synaptic plasticity in the rodent prefrontal cortex (PFC), linking long-term memory formation and dopaminergic modulation to executive functions.
Area of Science:
- Neuroscience
- Cognitive Science
- Behavioral Science
Background:
- Mnemonic functions involve both working memory and long-term memory.
- Working memory relies on persistent neural activity, while long-term memory involves synaptic plasticity.
- Executive functions, mediated by the prefrontal cortex (PFC), have been extensively studied regarding working memory, but less so regarding long-term memory.
Purpose of the Study:
- To review cellular mechanisms of synaptic plasticity in the medial rodent PFC.
- To explore the link between synaptic plasticity, memory, and behavior in PFC-dependent tasks.
- To highlight the role of dopaminergic modulation in prefrontal synaptic plasticity and executive functions.
Main Methods:
- Review of experimental data and theoretical work.
- Focus on cellular mechanisms of synaptic plasticity.
- Analysis of dopaminergic modulation in the PFC.
Main Results:
- Synaptic plasticity in the PFC is crucial for forming the structural basis of long-term memory.
- Dopaminergic modulation uniquely influences prefrontal synaptic plasticity.
- This plasticity is integral to executive functions.
Conclusions:
- Long-term memory, through synaptic plasticity in the PFC, plays a significant role in executive functions.
- Dopamine's modulation of PFC plasticity is key to understanding executive functions.
- Further research into these mechanisms can advance our understanding of memory and behavior.
Keywords:
behavioral flexibilitycomputational modelsdopamineexecutive functionslong-term memoryneuromodulationprefrontal cortexsynaptic plasticityMore Related Videos
09:39Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
27.1K
07:25Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
Published on: March 27, 2018
8.7K
Related Concept Videos
01:23Role of Neurotransmitters in Memory
710
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
710
01:14Role of Cerebellum and Prefrontal Cortex in Memory
546
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
546
01:03Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
01:35Long-term Potentiation
55.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.5K
01:30Attention-Deficit/Hyperactivity Disorder
140
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
140
01:16Role of Amygdala in Memory
343
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
343