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Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds
Qunpeng Duan1, Ran Chen1, Su Deng1
1School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China.
Frontiers in Chemistry
|January 30, 2023
Summary
Cucurbit[n]urils are widely used in fluorescent-indicator displacement assays (F-IDAs) to create luminescent sensors for detecting organic compounds. This review covers advances, challenges, and future directions in this sensing technology.
Area of Science:
- Supramolecular Chemistry
- Analytical Chemistry
- Chemical Sensing
Background:
- Fluorescent-indicator displacement assays (F-IDAs) enable the conversion of synthetic receptors into luminescent sensors.
- Cucurbit[n]urils possess rigid structures and high binding affinities, making them suitable for F-IDAs.
- These systems are effective for selective sensing of non-fluorescent or weakly fluorescent organic compounds.
Purpose of the Study:
- To review recent advancements in cucurbit[n]uril-based fluorescent-indicator displacement assays.
- To discuss the current challenges and future prospects in this field of chemical sensing.
Main Methods:
- Utilizing cucurbit[n]urils as host molecules.
- Employing fluorescent guests for indicator displacement.
- Applying F-IDAs for the detection of analytes.
Main Results:
- Cucurbit[n]uril-based F-IDAs have shown significant utility in selective and specific sensing.
- Recent designs have expanded the application scope of these luminescent sensors.
- The review highlights the successful application of F-IDAs in detecting various organic compounds.
Conclusions:
- Cucurbit[n]uril-based F-IDAs represent a powerful platform for developing luminescent sensors.
- Further research is needed to address current challenges and unlock future potential.
- This sensing strategy offers promising avenues for analytical applications.
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