Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds
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Updated: Aug 12, 2025

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
Qunpeng Duan1, Ran Chen1, Su Deng1
1School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China.
Abstract:
The widespread conversion of synthetic receptors into luminescent sensors has been achieved via the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[n]urils, combined with a variety of fluorescent guests, have gained extensive utilization in fluorescent-indicator displacement assays for sensing non-fluorescent or weakly fluorescent organic compounds (analytes) in a selective and specific manner. This mini-review summarizes recent advances in the design of cucurbit[n]uril-based fluorescent-indicator displacement assays and discusses the current challenges and future prospects in this area.
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