Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

230
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
230

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum Isolevuglandin IgG Antibody Concentrations Are Increased in Patients with Systemic Lupus Erythematosus and Associated with Lower 24-Hour Blood Pressure.

Frontiers in lupus·2026
Same author

Albuminuria Changes as a surrogate endpoint in <i>Apolipoprotein L1</i> Mediated Kidney Disease in Vanderbilt BioVU and the Million Veteran Program.

medRxiv : the preprint server for health sciences·2026
Same author

Evaluating Large Language Models for Translating Multimodal Phenotype Documentations into Executable EHR Phenotyping Algorithms.

Research square·2026
Same author

Evaluating Large Language Models for Translating Multimodal Phenotype Documentations into Executable EHR Phenotyping Algorithms.

medRxiv : the preprint server for health sciences·2026
Same author

Integrating genetically predicted transcriptomic signatures with longitudinal real-world data enables scalable drug repurposing for Alzheimer's disease.

Research square·2026
Same author

Multi-scale data improves performance of machine learning model for long COVID identification.

Communications medicine·2026

Related Experiment Video

Updated: Aug 12, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.0K

Association Between Genetically Predicted Expression of TPMT and Azathioprine Adverse Events.

Alyssa Davis1, Alyson L Dickson1, Laura L Daniel1

  • 1Vanderbilt University Medical Center.

Research Square
|January 30, 2023
PubMed
Summary

Genetic factors like TPMT influence azathioprine side effects. Lower predicted TPMT expression significantly increased leukopenia risk in a study of 1364 patients, suggesting a tool for personalized medicine.

Keywords:
azathioprinepharmacogenomicsrheumatologythiopurine methyltransferase

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.1K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

818

Related Experiment Videos

Last Updated: Aug 12, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.0K
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.1K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

818

Area of Science:

  • Pharmacogenomics
  • Computational Biology
  • Clinical Pharmacology

Background:

  • Known thiopurine-S-methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) polymorphisms increase azathioprine myelotoxicity risk.
  • Limited understanding of other genetic factors contributing to azathioprine-associated adverse drug reactions.
  • Need for advanced methods to identify genetic associations with drug side effects.

Conclusions:

  • Genetically predicted low TPMT expression is associated with an increased risk of azathioprine-induced leukopenia.
  • PrediXcan methodology shows promise for uncovering novel genetic associations with drug side effects.
  • This approach could facilitate personalized medicine strategies for azathioprine therapy.