Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arousal state modulates human hippocampal ripples.

bioRxiv : the preprint server for biology·2026
Same author

Virtual Responsive Neurostimulation Implantation: From Intracranial Connectivity to Optimized Lead Placement.

medRxiv : the preprint server for health sciences·2026
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

Association between Interictal Spike Rate and Seizure Frequency in a Large Epilepsy Cohort.

medRxiv : the preprint server for health sciences·2026
Same author

Coming out to parents/caregivers: Qualitatively investigating sexual and gender minority adults' reflections on less-validating responses.

Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)·2026
Same author

Hippocampal volume alterations in opioid use disorder: Evidence for posterior vulnerability and heterogeneity.

Drug and alcohol dependence·2026

Related Experiment Video

Updated: Aug 12, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K

Subcortical Functional Connectivity Gradients in Temporal Lobe Epilepsy.

Alfredo Lucas1,2, Sofia Mouchtaris2, Eli J Cornblath3

  • 1Perelman School of Medicine, University of Pennsylvania.

Medrxiv : the Preprint Server for Health Sciences
|January 30, 2023
PubMed
Summary

Subcortical functional gradients reveal brain differences in temporal lobe epilepsy (TLE). Abnormalities in the hippocampus are key to distinguishing left (L)-TLE from right (R)-TLE.

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.5K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.2K

Related Experiment Videos

Last Updated: Aug 12, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.5K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.2K

Area of Science:

  • Neuroimaging
  • Brain Connectivity
  • Epilepsy Research

Background:

  • Functional gradients are crucial for understanding brain connectivity in health and disease.
  • The subcortex's role in temporal lobe epilepsy (TLE) seizure initiation necessitates subcortical functional-connectivity gradient analysis.
  • Investigating subcortical gradients can differentiate TLE from healthy brains and distinguish between left (L)-TLE and right (R)-TLE.

Approach:

  • Calculated subcortical functional-connectivity gradients (SFGs) using resting-state functional MRI (rs-fMRI).
  • Measured connectivity profile similarity between subcortical and cortical gray matter voxels.
  • Analyzed SFG deviations and variance in 23 R-TLE, 32 L-TLE patients, and 16 controls.

Key Points:

  • Found an expansion (increased variance) in the principal SFG of TLE patients compared to controls.
  • Identified significant differences in ipsilateral hippocampal gradient distributions between L-TLE and R-TLE.
  • Abnormalities in SFGs are characteristic of TLE.

Conclusions:

  • Subcortical functional gradient expansion is a hallmark of TLE.
  • Distinct subcortical functional gradient patterns exist between L-TLE and R-TLE.
  • Hippocampal connectivity changes ipsilateral to the seizure onset zone drive these TLE-specific gradient differences.