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Related Experiment Videos

Tolerance to diazepam-induced avoidance depression in mice.

M Sansone1, P Renzi, J Vetulani

  • 1Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.

Polish Journal of Pharmacology and Pharmacy
|January 1, 1987
PubMed
Summary

Tolerance rapidly develops to diazepam, a benzodiazepine, which can disrupt avoidance responses. Repeated diazepam administration prevents this disruptive effect, indicating rapid tolerance to its behavioral actions.

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Psychopharmology

Background:

  • Benzodiazepines, such as diazepam, are known to affect behavior, including avoidance responses.
  • Understanding the development of tolerance to benzodiazepines is crucial for their therapeutic application and understanding of their mechanisms of action.

Purpose of the Study:

  • To investigate the development of tolerance to the behavioral effects of diazepam, specifically its action on avoidance responses.
  • To determine if pretreatment with diazepam can prevent or attenuate diazepam-induced avoidance depression in a shuttle-box training paradigm.

Main Methods:

  • Mice were trained in a shuttle-box to learn avoidance responses.
  • Diazepam (5 mg/kg) was administered before training sessions.
  • Pretreatment regimens involved daily administration of diazepam (5 mg/kg) for varying durations (one, three, or five days) prior to testing.

Main Results:

  • Diazepam administered during shuttle-box training disrupted avoidance responses.
  • A five-day pretreatment with diazepam abolished this disruptive action.
  • Pretreatment with diazepam, even a single dose, prevented or attenuated diazepam-induced avoidance depression in trained mice.

Conclusions:

  • Rapid tolerance develops to the diazepam-induced avoidance depression.
  • This finding is consistent with the rapid development of tolerance to other behavioral effects of benzodiazepines.
  • Tolerance to diazepam's behavioral actions can be induced through various pretreatment regimens.

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