Related Experiment Video
Updated: Aug 12, 2025
Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening
Published on: April 1, 2016
Caffeine-tolerant mutations selected through an at-home yeast experimental evolution teaching lab
Naomi G Moresi1, Renee C Geck1, Ryan Skophammer2
1Department of Genome Sciences, University of Washington, Seattle, WA 98195.
High school students can now study evolution at home using yeast experiments. This new protocol reveals novel genetic insights into how yeast develops caffeine tolerance through evolution.
Area of Science:
- Evolutionary biology
- Microbiology
- Genetics
Background:
- The yEvo curriculum uses yeast evolution experiments for high school education.
- Adapting hands-on science curricula for remote learning presents unique challenges.
Conclusions:
- The developed at-home protocol is effective for studying yeast evolution and adaptation.
- Novel genetic mechanisms contributing to caffeine tolerance in yeast were identified.
- This accessible experimental approach provides valuable insights for both education and scientific research.
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