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Operant Conditioning01:21

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Operant conditioning, a key concept in behavioral psychology, involves using reinforcement and punishment to alter the likelihood of a behavior being repeated. B.F. introduced this type of conditioning. Skinner focused on voluntary behaviors and the consequences that follow them, influencing whether these behaviors will be strengthened or diminished.
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A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments
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An Open-Source Platform for Head-Fixed Operant and Consummatory Behavior.

Adam Gordon-Fennell1, Joumana M Barbakh1, MacKenzie Utley1

  • 1Center for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, 98195, Seattle, WA, USA.

Biorxiv : the Preprint Server for Biology
|January 30, 2023
PubMed
Summary
This summary is machine-generated.

We developed OHRBETS, an affordable, open-source system for head-fixed rodent behavior experiments. This customizable ecosystem enables precise study of motivated behaviors and neural activity in mice.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Biomedical Engineering

Background:

  • Head-fixed rodent models offer high experimental control for studying behavior and neural activity.
  • Existing systems can be costly and lack flexibility for diverse research needs.

Approach:

  • Introduced OHRBETS (Open-Source Head-fixed Rodent Behavioral Experimental Training System), a low-cost, modular hardware and software ecosystem.
  • Designed for flexible implementation of operant conditioning, intracranial self-stimulation, and real-time place preference tasks.
  • Integrated multi-spout lickometers for detailed analysis of consummatory behaviors and sensory evaluation.

Key Points:

  • OHRBETS successfully replicated core behavioral phenotypes of operant conditioning in head-fixed mice.
  • The system facilitated optogenetic self-stimulation and real-time place preference assays.
  • Mice exhibited concentration-dependent licking in a brief-access task, modulated by circadian and homeostatic factors.
  • Mesolimbic dopamine signals correlated with solution value and consumption magnitude during the task.

Conclusions:

  • OHRBETS provides a customizable, open-source platform for reproducible head-fixed rodent behavioral experiments.
  • The ecosystem supports the investigation of the neural basis of motivated behaviors.
  • OHRBETS can be readily combined with in vivo neural recording and perturbation techniques.