Related Experiment Video

Updated: Aug 12, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K

Screening for key genes in circadian regulation in advanced atherosclerosis: A bioinformatic analysis

Jiali Yao1, Jingyan Liang1,2, Hongliang Li1,2

  • 1Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China.

Frontiers in Cardiovascular Medicine
|January 30, 2023
PubMed

Insights

This study identifies two key circadian rhythm genes linked to advanced atherosclerosis (AS). These genes may offer new therapeutic targets for cardiovascular disease, improving our understanding of AS pathogenesis.

Area of Science:

  • Cardiovascular Research
  • Chronobiology
  • Bioinformatics

Background:

  • Atherosclerosis (AS) is a major cause of cardiovascular disease, including myocardial infarction and stroke.
  • While AS pathogenesis is increasingly understood, the role of circadian regulation remains unclear.
  • Circadian rhythms influence numerous physiological processes, and their disruption is implicated in various diseases.

Purpose of the Study:

  • To investigate the relationship between circadian regulation and atherosclerosis pathogenesis.
  • To identify key circadian rhythm-associated genes involved in AS.
  • To explore potential new therapeutic targets for AS.

Main Methods:

  • Utilized bioinformatics analysis, including Weighted Gene Co-expression Network Analysis (WGCNA) and Lasso regression.
  • Downloaded and analyzed early and advanced AS patient samples from public databases.
  • Assessed immune cell infiltration using CIBERSORT and analyzed gene-immune cell relationships.

Main Results:

  • Identified two core circadian rhythm-related genes significantly associated with advanced AS.
  • These genes were found to influence immune cell infiltration in late-stage AS.
  • Receiver Operating Characteristic (ROC) curves confirmed the efficacy of these genes in distinguishing between early and advanced AS.

Conclusions:

  • Two novel circadian rhythm genes strongly associated with advanced AS were identified.
  • The elucidated association of these genes with AS suggests their potential as future therapeutic targets.
  • This research provides novel insights into the interplay between circadian rhythm and AS development.
Abstract

Keywords:
C3aR1CCR1WGCNAatherosclerosiscircadian rhythm

More Related Videos

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.6K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
103
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
44
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
32
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
26