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Inflammation index SIRI is associated with increased all-cause and cardiovascular mortality among patients with

Songfeng Zhao1, Siyuan Dong1, Yongkai Qin1

  • 1Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Cardiovascular Medicine
|January 30, 2023
PubMed

Insights

The systemic inflammatory response index (SIRI) is linked to higher mortality in hypertension patients. Elevated SIRI indicates increased risk for all-cause and cardiovascular death, suggesting its potential as a clinical biomarker.

Area of Science:

  • Cardiovascular Research
  • Inflammation Biomarkers
  • Hypertension Studies

Background:

  • Inflammation is crucial in hypertension development.
  • The systemic inflammatory response index (SIRI) is a novel biomarker linked to mortality.
  • The role of SIRI in hypertension patients remains unclear.

Purpose of the Study:

  • To investigate the association between SIRI and mortality in hypertension patients.
  • To evaluate SIRI as a prognostic biomarker in hypertension.

Main Methods:

  • Utilized data from 21,506 hypertension patients in NHANES (1999-2018).
  • Calculated SIRI (neutrophil count * monocyte count/lymphocyte count).
  • Employed Kaplan-Meier curves, weighted Cox regression, and ROC analysis for mortality assessment.

Main Results:

  • A J-shaped association was found between SIRI and all-cause/cardiovascular mortality.
  • Higher SIRI quartiles correlated with increased mortality risks.
  • Elevated SIRI showed a significant positive association with all-cause (HR=1.19) and CVD mortality (HR=1.19).

Conclusions:

  • Elevated SIRI is associated with increased all-cause and cardiovascular mortality in hypertension.
  • SIRI shows potential as a valuable inflammatory biomarker in clinical practice.
  • Further large-scale studies are needed to validate these findings.
Abstract

Keywords:
National Health and Nutrition Examination Survey (NHANES)hypertensioninflammationmortalitysystemic inflammatory response index (SIRI)

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