Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Motor automaticity in natural keyboard typing.

bioRxiv : the preprint server for biology·2026
Same author

The Prodromal Synucleinopathy Rating Scale: An Assessment in Patients With REM Sleep Behavior Disorder.

Neurology·2026
Same author

Combined accelerometry and writing analysis for quantifying tremor during focused ultrasound thalamotomy.

Journal of neurosurgery·2026
Same author

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

NPJ Parkinson's disease·2026
Same author

Filtered-phase imaging versus susceptibility-weighted imaging for paramagnetic rim lesion detection in multiple sclerosis: A head-to-head comparison.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Remarkable response to radiation in a non-enhancing diffuse pediatric-type high-grade glioma with germline <i>ATM</i> mutation: The role of PET imaging and integrated histological and molecular analysis.

Neuro-oncology advances·2026
Same journal

Mind the gender gap: how defining head trauma increases reporting in women aged 30-50.

Frontiers in neurology·2026
Same journal

Traditional Chinese medicine interventions for post-stroke cognitive impairment: an evidence mapping.

Frontiers in neurology·2026
Same journal

Acupuncture is independently associated with improved recovery in Guillain-Barré syndrome: a prospective observational study.

Frontiers in neurology·2026
Same journal

A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders.

Frontiers in neurology·2026
Same journal

Lumbar puncture opening pressure, brain network hub integrity, and delirium in herpes simplex virus encephalitis: a prospective cohort study.

Frontiers in neurology·2026
Same journal

Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.

Frontiers in neurology·2026
See all related articles

Related Experiment Video

Updated: Aug 12, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.1K

Oxidative stress in multiple sclerosis-Emerging imaging techniques.

Christopher Hollen1,2, Lee E Neilson1,2, Ramon F Barajas3,4,5

  • 1Department of Neurology, Veterans Affairs Medical Center, Portland, OR, United States.

Frontiers in Neurology
|January 30, 2023
PubMed
Summary
This summary is machine-generated.

Oxidative stress contributes to neurodegeneration in multiple sclerosis (MS). New imaging techniques are needed to detect this oxidative stress early, before irreversible damage occurs in MS patients.

Keywords:
glutathionemagnetic resonance imagingmagnetic resonance spectroscopyoxidative stresspositron emission tomographyprogressive multiple sclerosis

More Related Videos

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.2K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K

Related Experiment Videos

Last Updated: Aug 12, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.1K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.2K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K

Area of Science:

  • Neuroscience
  • Radiology
  • Biochemistry

Background:

  • Conventional magnetic resonance imaging (MRI) has limitations in detecting early neurodegeneration in multiple sclerosis (MS).
  • Current outcome measures like brain atrophy are non-specific and reflect late-stage disease.
  • Oxidative stress is increasingly recognized as a key factor in the pathogenesis of MS and other neurodegenerative diseases.

Purpose of the Study:

  • To review the role of oxidative stress in multiple sclerosis pathogenesis.
  • To discuss emerging imaging techniques for assessing oxidative stress in MS.
  • To highlight the need for early, non-invasive biomarkers for neurodegeneration.

Main Methods:

  • Review of existing literature on oxidative stress in MS.
  • Discussion of advanced imaging techniques under development for neurodegenerative diseases.
  • Evaluation of blood and cerebrospinal fluid (CSF) markers of oxidative stress.

Main Results:

  • Oxidative stress, driven by chronic inflammation and reactive oxygen species, significantly contributes to MS pathogenesis.
  • Aging and disease progression can amplify the effects of oxidative stress.
  • While blood and CSF markers exist, non-invasive brain imaging offers real-time assessment of oxidative stress.

Conclusions:

  • Oxidative stress is a critical, yet underexplored, target in multiple sclerosis.
  • Developing non-invasive imaging biomarkers for oxidative stress is crucial for early detection and intervention in MS.
  • Advanced imaging holds promise for real-time assessment of neurodegenerative processes in MS.