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Blood lactate changes during exercise at high altitude.

N Binns1, A D Wright, B M Singh

  • 1Department of Medicine, University of Birmingham, UK.

Postgraduate Medical Journal
|March 1, 1987
PubMed
Summary
This summary is machine-generated.

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High altitude exercise significantly reduced blood lactate concentrations in normal subjects. Lower lactate levels correlated with higher basal pH and lower oxygen levels, suggesting pH is a key factor.

Area of Science:

  • Exercise Physiology
  • Altitude Physiology
  • Biochemistry

Background:

  • Exercise elicits metabolic changes, including lactate production.
  • High altitude exposure induces physiological adaptations.
  • Understanding lactate metabolism is crucial for performance and health.

Purpose of the Study:

  • To investigate the impact of high altitude on blood lactate concentrations during strenuous exercise.
  • To explore correlations between lactate levels, blood gases, pH, and acute mountain sickness.

Main Methods:

  • 18 healthy subjects underwent a 15-minute exercise test at 85% maximum heart rate.
  • Blood lactate concentrations were measured post-exercise at high altitude (4846 m).
  • Correlations with basal pH, PaO2, acetazolamide use, and AMS severity were analyzed.

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Main Results:

  • Blood lactate concentrations were reduced at high altitude compared to normobaric conditions.
  • Lactate levels showed a positive correlation with basal pH and a negative correlation with basal PaO2.
  • Acetazolamide use was associated with lower lactate, but no correlation was found with AMS severity or workload.

Conclusions:

  • pH changes appear to be the most significant factor in reducing blood lactate concentrations at high altitude.
  • High altitude exercise alters lactate metabolism, influenced by respiratory and acid-base status.
  • Further research is warranted to elucidate the precise mechanisms involved.