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Association between fibrinogen/albumin ratio and arterial stiffness in patients with type 2 diabetes: A

Chun-Mei Chen1, Chun-Feng Lu2, Wang-Shu Liu2

  • 1Department of Geriatrics, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, Nantong, China.

Frontiers in Pharmacology
|January 30, 2023
PubMed

Insights

The fibrinogen albumin ratio (FAR) is linked to arterial stiffness in men with type 2 diabetes. This ratio may help detect arterial stiffness in male T2D patients.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Biomarkers

Background:

  • Fibrinogen albumin ratio (FAR) correlates with cardiovascular disease (CVD) severity and prognosis.
  • Arterial stiffness, an early CVD lesion, has not been previously linked to FAR.
  • Investigating the relationship between FAR and arterial stiffness in type 2 diabetes (T2D) is crucial.

Purpose of the Study:

  • To examine the relationship between FAR and arterial stiffness in T2D patients.
  • To assess arterial stiffness using brachial-ankle pulse wave velocity (baPWV).
  • To determine if FAR is an independent predictor of arterial stiffness in T2D.

Main Methods:

  • Cross-sectional study of 413 T2D patients (Jan 2021-Apr 2022).
  • Measured serum fibrinogen, albumin, and baPWV.
  • Defined arterial stiffness as baPWV > 1800 cm/s.

Main Results:

  • 18.6% of T2D patients had arterial stiffness.
  • Significant differences in baPWV and arterial stiffness proportion across FAR quartiles (p < .001).
  • FAR independently associated with arterial stiffness in men with T2D (OR 1.075; 95% CI 1.031-1.120).
  • Optimal FAR cutoff for arterial stiffness in men: 76.67 mg/g.

Conclusions:

  • FAR shows an independent, positive correlation with arterial stiffness in male T2D patients.
  • This correlation was not observed in female T2D patients.
  • FAR may serve as a potential biomarker for arterial stiffness in men with T2D.

Keywords:
brachial-ankle pulse wave velocitycoagulationfibrinogen/albumin ratioinflammationtype 2 diabetes

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