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The Spontaneous Regression of Primary Gastrointestinal Malignancies: An Observational Review

Carlos D Minacapelli1, Philip Leuszkiewicz2, Ankoor Patel3

  • 1Medicine, Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.

Cureus
|January 30, 2023
PubMed

Insights

Spontaneous cancer regression (SR) is a rare event where tumors disappear without treatment. This study reviews 390 gastrointestinal cases, focusing on the hepatobiliary system, and updates criteria for identifying SR.

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Spontaneous regression (SR) of cancer, the disappearance of tumors without therapy, is a rare but significant phenomenon.
  • Understanding SR in gastrointestinal (GI) malignancies is crucial for developing novel cancer treatments with fewer adverse effects.

Purpose of the Study:

  • To conduct a comprehensive review of spontaneous regression in the GI tract.
  • To propose updated inclusion criteria for SR, incorporating recent scientific advancements.

Main Methods:

  • Analysis of 390 documented cases of spontaneous regression in the GI tract.
  • Focus on neoplasms within the hepatobiliary system.

Main Results:

  • Identified and analyzed a substantial cohort of SR cases within the GI tract.
  • The study provides a detailed examination of SR, particularly in hepatobiliary cancers.

Conclusions:

  • Existing inclusion criteria for SR require updating to reflect current medical technology and understanding.
  • This research contributes to a better understanding of SR and its potential therapeutic implications.
Keywords:
gastroenterologygastrointestinal cancershepatobiliary systemhepatocellular carcinomahepatologyneoplasmsoncologyspontaneous regressionspontaneous remission

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