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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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P53 protein and the diseases in central nervous system

Li Lei1, Qixiong Lu1, Guifang Ma2

  • 1The Affiliated Hospital of Kunming University of Science and Technology, The Department of Neurosurgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.

Frontiers in Genetics
|January 30, 2023
PubMed

Insights

The P53 tumor suppressor gene is crucial for fighting cancers. Recent studies highlight its significant role in central nervous system (CNS) diseases, including tumors, stroke, and neurodegeneration.

Area of Science:

  • Oncology
  • Neuroscience
  • Molecular Biology

Background:

  • The P53 gene product, P53 protein, is a critical tumor suppressor and cell cycle regulator.
  • While P53's anti-cancer functions are well-established in various organs, its role in the central nervous system (CNS) is less explored.
  • Emerging evidence indicates P53's involvement in CNS pathologies.

Purpose of the Study:

  • To review the multifaceted roles of P53 in CNS tumors.
  • To elucidate P53's mechanisms in cerebral stroke and neurodegenerative diseases.
  • To consolidate current research and propose future directions for P53-targeted CNS therapies.

Main Methods:

  • Comprehensive literature review of studies on P53 and CNS diseases.
  • Analysis of P53's involvement in oncogenesis within the CNS.
  • Examination of P53's function in neuroprotection and neurodegeneration.

Main Results:

  • P53 is implicated in the development and progression of diverse CNS tumors.
  • P53 pathways are significantly altered in cerebral stroke, influencing outcomes.
  • Dysregulation of P53 contributes to the pathogenesis of neurodegenerative disorders.

Conclusions:

  • P53 is a key player in CNS tumor suppression and has critical roles in neurological diseases.
  • Understanding P53 mechanisms in the CNS opens avenues for novel therapeutic strategies.
  • Further research into P53's complex functions in the CNS is warranted.
Keywords:
P53apoptosiscerebral strokeferroptosisgliomasneurodegenerative diseasesneuroinflammation

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