Related Experiment Video

Updated: Aug 12, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.4K

Prognostic and Immunological Potential of Ribonucleotide Reductase Subunits in Liver Cancer

Xin Yin1, Kan Jiang1, Ziyang Zhou1

  • 1Department of Radiation Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003, China.

Oxidative Medicine and Cellular Longevity
|January 30, 2023
PubMed
Abstract

Insights

Ribonucleotide reductase (RR) subunits RRM1, RRM2, and RRM2B are highly expressed in liver cancer. Their elevated expression correlates with poor prognosis and predicts chemosensitivity, offering new insights for treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Ribonucleotide reductase (RR) is crucial for DNA replication and its dysregulation is linked to cancer.
  • The specific roles and expression patterns of RR subunits (RRM1, RRM2, RRM2B) in liver cancer require further investigation.

Purpose of the Study:

  • To investigate the expression profiles and biological functions of RR subunits in liver cancer.
  • To explore the prognostic and therapeutic implications of RR subunit expression in liver cancer.

Main Methods:

  • Utilized TCGA, HCCDB, CCLE, HPA, cBioPortal, and GeneMANIA for bioinformatics analysis.
  • Performed Gene Ontology (GO), KEGG, and Gene Set Enrichment Analysis (GSEA) for enrichment analysis.

Main Results:

  • RRM1, RRM2, and RRM2B mRNA and protein levels were significantly upregulated in liver cancer.
  • High RRM1/RRM2 expression correlated with advanced tumor grade/stage and poorer survival outcomes.
  • RR subunits are implicated in DNA replication, cell cycle, DNA repair, and are associated with immune cell infiltration and chemosensitivity.

Conclusions:

  • High expression of RR subunits in liver cancer is associated with poor prognosis.
  • RR subunit expression may serve as a predictive biomarker for chemosensitivity in liver cancer treatment.

More Related Videos

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

10.4K
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.3K

Related Concept Videos

The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
9.0K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.6K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.3K