Endothelial cell metabolism in sepsis

Area of Science:

• Biomedical Science
• Cell Biology
• Pathophysiology

Background:

• Endothelial dysfunction is a key feature of septic organ failure.
• Endothelial cells (ECs) possess unique metabolic adaptations to maintain vascular homeostasis during sepsis.

Purpose of the Study:

• To review and synthesize current knowledge on endothelial cell metabolism in sepsis.
• To provide an overview of EC metabolic pathways and their role in sepsis progression.

Main Methods:

• Comprehensive literature search of Web of Science and PubMed up to October 2022.
• Inclusion of English-language articles focusing on EC metabolism in sepsis.
• Independent review by two researchers to identify relevant studies.

Main Results:

• Sixty studies, primarily cell and animal models, were included.
• Key metabolic pathways discussed include glycolysis, oxidative phosphorylation, fatty acid, and amino acid metabolism.
• Dysregulation in these EC metabolic pathways can exacerbate sepsis progression.

Conclusions:

• Current research on EC metabolism in sepsis is predominantly basic science.
• Significant gaps exist in clinical studies.
• This review offers a consolidated understanding and highlights novel perspectives on EC metabolism in sepsis.