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Polyvalent human immunoglobulin for infectious diseases: Potential to circumvent antimicrobial resistance

Sigifredo Pedraza-Sánchez1, Adrián Cruz-González2, Oscar Palmeros-Rojas3

  • 1Unidad de Bioquímica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Frontiers in Immunology
|January 30, 2023
PubMed

Insights

Antimicrobial resistance (AMR) is a growing threat. This review explores using polyvalent human immunoglobulin (IVIG) as a potential strategy to combat drug-resistant infections by enhancing natural immunity.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Microbiology

Background:

  • Antimicrobial resistance (AMR) is a critical global health crisis, leading to over 1.27 million deaths annually.
  • The overuse and misuse of antimicrobials in human, animal, and agricultural sectors accelerate the selection of drug-resistant pathogens.
  • Developing novel strategies to combat AMR is urgently needed.

Purpose of the Study:

  • To review the evidence supporting the use of polyvalent human immunoglobulin (IVIG) as a therapeutic approach against antimicrobial resistance.
  • To evaluate the potential benefits and challenges of employing IVIG in managing drug-resistant infections.

Main Methods:

  • This review synthesizes existing experimental data and scientific literature.
  • It focuses on the mechanism of action of IVIG in enhancing natural immunity.
  • The review examines findings related to both intravenous and local administration of IVIG.

Main Results:

  • Polyvalent human immunoglobulin (IVIG) offers a passive immunization strategy that bolsters the host's natural defense mechanisms.
  • IVIG has demonstrated the capacity to safely and physiologically aid in the elimination of bacteria, viruses, and fungi.
  • Preliminary data suggest local IVIG administration might be more effective at lower doses than intravenous application for certain infections.

Conclusions:

  • IVIG presents a promising adjunctive therapy for combating antimicrobial resistance.
  • Further research is warranted to fully understand the potential and overcome the challenges of IVIG in clinical AMR management.
  • Exploring optimized administration routes, such as local delivery, could enhance IVIG's efficacy and safety profile.
Keywords:
antibiotic stewardshipantimicrobial resistancehuman immunoglobulininfection controlinfectious diseasesmisuse of antibioticspublic health

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