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Updated: Aug 12, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Research progress on circular RNA vaccines
Yu Bai1,2,3, Dong Liu1,2,3, Qian He1,2,3
1Division of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, China.
Abstract:
Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.
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