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Related Experiment Video

Updated: Aug 12, 2025

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

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Published on: November 11, 2017

Changing subplate circuits: Early activity dependent circuit plasticity.

Didhiti Mukherjee¹, Patrick O Kanold^1,2

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.

Frontiers in Cellular Neuroscience

|January 30, 2023

Summary

This summary is machine-generated.

Subplate neurons (SPNs) are crucial for developing sensory circuits. Early sensory deprivation impacts SPNs, potentially leading to neurodevelopmental disorders.

Keywords:

activity-dependent plasticity development sensory-driven activity spontaneous activity subplate neurons

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Area of Science:

Neuroscience
Developmental Biology
Neurophysiology

Background:

Early neural activity sculpts developing sensory systems.
Subplate neurons (SPNs) are transient, early-born neurons vital for cortical development.
SPNs integrate spontaneous and sensory-driven activity.

Conclusions:

SPNs play a critical role in establishing mature cortical connectivity.
Altered SPN function due to sensory deprivation may contribute to neurodevelopmental disorders.
Understanding SPN roles is key to addressing developmental brain conditions.