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Effect of TRIB1 Variant on Lipid Profile and Coronary Artery Disease: A Systematic Review and Meta-Analysis

Baozhu Wei1,2, Yang Liu3, Hang Li4

  • 1Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Cardiovascular Therapeutics
|January 30, 2023
PubMed

Insights

Tribbles homolog 1 (Trib1) gene variants (rs17321515 and rs2954029) are linked to higher cholesterol and coronary artery disease (CAD) risk, particularly in Asian populations.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Metabolic Disorders

Background:

  • Tribbles homolog 1 (Trib1) protein's role in lipid metabolism and coronary artery disease (CAD) pathogenesis is under investigation.
  • The impact of specific TRIB1 gene variants on lipid profiles and CAD risk requires clarification.

Approach:

  • A comprehensive meta-analysis was conducted, including 108,831 individuals from studies published before December 18, 2022.
  • PubMed and Cochrane databases were systematically searched to identify relevant research.

Key Points:

  • Carriers of the A allele for TRIB1 variants rs17321515 and rs2954029 exhibited elevated levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC).
  • A statistically significant association was found between these TRIB1 variants and an increased risk of CAD.
  • Subgroup analysis revealed that the observed increases in LDL-C, TC, and CAD risk were particularly pronounced in the Asian population.

Conclusions:

  • TRIB1 gene variants, specifically rs17321515 and rs2954029, may function as causal genetic markers for dyslipidemia.
  • These TRIB1 variants are potentially significant contributors to CAD pathogenesis, especially within the Asian demographic.
Abstract

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