Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Gastric cancer (GC) remains a leading cause of cancer mortality worldwide, with poor prognoses despite treatment advancements.
• Mitochondrial dynamics and dysfunction are increasingly recognized as critical factors in cancer cell growth and progression.
• Non-coding RNAs (ncRNAs) have emerged as key regulators in various cancers, including GC.

Purpose of the Study:

• To review and summarize the molecular mechanisms underlying gastric cancer (GC) pathogenesis.
• To elucidate the role of non-coding RNAs (ncRNAs) in regulating mitochondrial dynamics in GC.
• To identify potential therapeutic targets by understanding the interplay between ncRNAs, mitochondria, and GC progression.

Main Methods:

• Literature review of studies investigating ncRNAs, mitochondrial dynamics, and gastric cancer.
• Analysis of the functions of oncogenes and tumor suppressors in regulating ncRNAs and mitochondrial dynamics.
• Synthesis of current knowledge on the pathogenesis and therapeutic interventions for GC.

Main Results:

• Non-coding RNAs (ncRNAs) significantly influence gastric cancer (GC) development and progression by modulating mitochondrial dynamics.
• Oncogenes and tumor suppressors play crucial roles in suppressing ncRNAs and altering mitochondrial dynamics, impacting GC tumor growth, invasion, and metastasis.
• The intricate crosstalk between ncRNAs and mitochondria is a key determinant in GC pathogenesis.

Conclusions:

• Elucidating the relationship between ncRNAs and mitochondrial dynamics provides novel insights into gastric cancer (GC) development.
• Targeting the interplay between ncRNAs and mitochondria presents a promising strategy for future GC prevention and treatment.
• This review highlights new avenues for understanding and intervening in GC pathogenesis.