Correlation between Aβ1-42, Dnmt3a2, urinary AD7c-NTP and cognitive dysfunction in first-episode and recurrent MDD: A
Zhigang Liu1, Yuxia Liu1, Xiaofeng Zhao1
1Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background And Aim:
Major depressive disorder (MDD) is one of the most prevalent mental illnesses worldwide and involves cognitive dysfunction that may negatively impact clinical and social outcomes. Previous studies have suggested that beta-amyloid peptide (Aβ1-42), DNA methyltransferase (Dnmt3a2), and urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) are associated with cognitive impairment. However, there are no relevant studies in MDD. The aim of this study was to assess the correlation between serum Aβ1-42, Dnmt3a2, and urinary AD7c-NTP and cognitive dysfunction in MDD.
Materials And Methods:
A total of 59 eligible patients were included in the study, including 29 patients with first-episode MDD (FEDs) and 30 patients with recurrent MDD (RMDDs), and 30 matched healthy controls (HCs) were selected. Participants' cognitive functioning was evaluated using the MATRICS consensus cognitive battery (MCCB). The enzyme-linked immunosorbent assay (ELISA) method was used to measure the concentrations of the three proteins. Statistical analysis was completed using Statistical Package for the Social Sciences (SPSS) 20.0. The statistical significance was set as P < 0.05.
Results:
Serum Dnmt3a2 and urinary AD7c-NTP showed significant differences among the three groups (both P < 0.001), but there were no significant differences in Aβ1-42 levels. Upon examining the results of cognitive testing, we found that serum Aβ1-42 was negatively associated with working memory scores in RMDDs (P = 0.020), but Dnmt3a2 was positively associated with working memory and verbal learning scores in the same cohort (P = 0.012 and P = 0.037, respectively). In contrast, urinary AD7c-NTP was negatively correlated with verbal learning scores in FEDs (P = 0.013).
Conclusions:
Serum Dnmt3a2 and Aβ1-42 levels may be associated with cognitive impairment in RMDDs and may act as potential biomarkers of cognitive impairment. Although urinary AD7c-NTP was closely related to cognitive dysfunction in FEDs, this relationship did not hold in RMDDs.
Insights
Serum Dnmt3a2 and beta-amyloid peptide (Aβ1-42) may indicate cognitive impairment in recurrent major depressive disorder (MDD). Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) showed links to cognitive issues in first-episode MDD.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Major depressive disorder (MDD) is a global mental health issue linked to cognitive dysfunction.
- Beta-amyloid peptide (Aβ1-42), DNA methyltransferase (Dnmt3a2), and urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) are implicated in cognitive impairment.
Purpose of the Study:
- To investigate the association between serum Aβ1-42, Dnmt3a2, and urinary AD7c-NTP with cognitive dysfunction in MDD patients.
Main Methods:
- Included 59 MDD patients (29 first-episode MDD, 30 recurrent MDD) and 30 healthy controls.
- Cognitive function assessed using the MATRICS Consensus Cognitive Battery (MCCB).
- Serum and urinary protein levels measured via ELISA; statistical analysis performed using SPSS.
Main Results:
- Significant differences in serum Dnmt3a2 and urinary AD7c-NTP were observed across groups (P < 0.001).
- Serum Aβ1-42 negatively correlated with working memory in recurrent MDD (P=0.020).
- Serum Dnmt3a2 positively correlated with working memory and verbal learning in recurrent MDD (P=0.012, P=0.037).
- Urinary AD7c-NTP negatively correlated with verbal learning in first-episode MDD (P=0.013).
Conclusions:
- Serum Dnmt3a2 and Aβ1-42 may serve as biomarkers for cognitive impairment in recurrent MDD.
- Urinary AD7c-NTP is associated with cognitive dysfunction in first-episode MDD but not recurrent MDD.
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