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Molecular insights into onset of autoimmunity in SARS-CoV-2 infected patients

Dama Laxminarayana1

  • 1Sathya Krishna Genomics LLC Winston-Salem North Carolina USA.

Rheumatology & Autoimmunity
|January 30, 2023
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger autoimmune diseases. Molecular mechanisms suggest SARS-CoV-2 may lead to autoantigen generation, causing autoimmunity in some patients.

Area of Science:

  • Immunology
  • Virology
  • Genetics

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with long-term complications, including the induction of autoimmune diseases.
  • Understanding the mechanisms behind SARS-CoV-2-mediated autoimmunity is crucial for managing post-infection sequelae.

Purpose of the Study:

  • To discuss the molecular mechanisms and risk factors involved in the induction of autoimmune diseases following SARS-CoV-2 infection.
  • To explore potential preventive strategies against SARS-CoV-2-induced autoimmunity.

Main Methods:

  • Review and commentary on existing literature regarding SARS-CoV-2 infection and autoimmune disease development.
  • Analysis of molecular pathways, including transcript editing and autoantigen presentation.

Main Results:

  • Upregulation of transcript editing genes during SARS-CoV-2 infection may lead to the generation of autoantigens.
  • These autoantigens, presented as non-self, can trigger autoantibody production and subsequent autoimmunity.
  • Transient or mild autoimmune responses may result from insufficient autoantibody production.

Conclusions:

  • SARS-CoV-2 infection can precipitate autoimmune diseases through specific molecular mechanisms.
  • Preventive measures and strategies are needed to mitigate the risk of developing autoimmune conditions post-SARS-CoV-2 infection.
  • Managing SARS-CoV-2-mediated autoimmune disease onset presents a future challenge requiring proactive interventions.
Keywords:
RNA editingSARS‐CoV‐2 pathogenesisautoimmunitycytokine stormmutationstype I interferons

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