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Neurological Complications in Benign Parapharyngeal Space Tumors - Systematic Review and Meta-Analysis
Muhammad Faisal1,2, Rudolf Seemann2, Gregor Fischer3
1Shaukat Khanum Memorial Cancer Hosital and Research Centre, Lahore, Pakistan.
International Archives of Otorhinolaryngology
|January 30, 2023
Summary
Neurologic complications after parapharyngeal space tumor surgery are linked to neurogenic tumors, not the surgical approach. This finding aids in managing these complex cases.
Area of Science:
- Otolaryngology
- Neurosurgery
- Oncology
Background:
- Parapharyngeal space tumors present complex anatomical and histological challenges.
- Identifying factors associated with postoperative complications is crucial for patient management.
Purpose of the Study:
- To determine factors associated with postoperative complications in parapharyngeal space tumors.
- To analyze the impact of tumor characteristics and surgical approach on outcomes.
Main Methods:
- A systematic review of multiple databases (PubMed, Web of Science, EMBASE, Cochrane Library, CBM, Clinicaltrials.gov) was performed.
- Data from 631 benign parapharyngeal space tumors across 13 studies were analyzed.
- Independent review by two researchers with third-party adjudication ensured data integrity.
Main Results:
- The most common histologies were salivary gland (50.8%) and neurogenic (49.1%) tumors.
- Tumor size, location, histology, and proximity to critical structures influenced surgical approach selection.
- Neurogenic histology significantly increased the risk of neurological complications (OR 6.07; p=0.001).
Conclusions:
- Neurologic complications are significantly associated with neurogenic benign tumors.
- The surgical approach does not appear to correlate with neurological sequelae.
