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Updated: Aug 12, 2025
04:09
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
Published on: September 20, 2024
355
Risk Factors for Malignancy in Patients with Multinodular Goiter
Guilherme Arruda Fernandes1, Leandro Luongo de Matos2, Rogério Aparecido Dedivitis2,3
1Faculdade de Ciências da Saúde, Universidade Metropolitana de Santos, Santos, SP, Brasil.
International Archives of Otorhinolaryngology
|January 30, 2023
Summary
Malignancy risk in multinodular goiter is linked to the Bethesda index, older age, shorter history, and fewer, smaller nodules. These factors help predict papillary carcinoma in thyroid cancer diagnosis.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Thyroid cancer identification involves clinical, imaging, and histopathological methods.
- Both solitary thyroid nodules and multinodular goiter carry malignancy risks.
Purpose of the Study:
- To evaluate risk factors for malignancy in patients with multinodular goiter undergoing total thyroidectomy.
- Identify predictors of papillary carcinoma in multinodular goiter.
Main Methods:
- Retrospective analysis of 712 patients who underwent total thyroidectomy for multinodular goiter (2005-2016).
- Evaluation of clinical, ultrasound, and pathological variables to assess malignancy risk.
Main Results:
- Papillary carcinoma was diagnosed in 57.3% of cases (408 patients).
- Significant risk factors for malignancy included higher Bethesda index, older age, shorter clinical history, fewer nodules, and smaller nodule size.
- Gender was not a statistically significant predictor of malignancy.
Conclusions:
- The Bethesda index, older age, shorter clinical history, fewer nodules, and smaller nodule size are associated with papillary carcinoma diagnosis.
- These factors are crucial for risk stratification in multinodular goiter patients.
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