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The Association between Placental Abruption and Platelet Indices

Duygu Tugrul Ersak1, Özgür Kara1, Kadriye Yakut1

  • 1Ankara Dr. Zekai Tahir Burak Women's Health Training Research Hospital, Ankara, Turkey.

Fetal and Pediatric Pathology
|January 30, 2023
PubMed

Insights

Platelet indices like mean platelet volume (MPV) and platelet to lymphocyte ratio (PLR) were lower, while platelet distribution width (PDW) was higher in patients with placental abruption (PA). These findings suggest potential diagnostic value for these markers in early PA assessment.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology

Background:

  • Placental abruption (PA) is a critical obstetric emergency.
  • Early diagnosis of PA is crucial for effective management and improved outcomes.

Purpose of the Study:

  • To investigate the utility of platelet indices in the early diagnosis of placental abruption (PA).
  • To assess if specific platelet parameters can aid in differentiating PA from other conditions.

Main Methods:

  • A case-control study involving 62 pregnant women with PA and 130 controls.
  • Analysis of platelet indices (MPV, PDW), biochemical, and coagulation parameters before cesarean section.
  • Recording of maternal and neonatal outcomes.

Main Results:

  • No significant differences in hemoglobin, hematocrit, or white blood cell count between groups.
  • Significantly lower platelet count, mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) in PA patients.
  • Significantly higher platelet distribution width (PDW) in PA patients compared to controls.

Conclusions:

  • Mean platelet volume (MPV) and platelet to lymphocyte ratio (PLR) were found to be lower in patients with placental abruption.
  • Platelet distribution width (PDW) was observed to be higher in placental abruption patients.
  • These platelet indices may serve as valuable biomarkers for the early assessment and diagnosis of placental abruption.

Keywords:
Placental abruptioninflammationmean platelet volumeplatelet distribution widthplatelet indicesplatelet to lymphocyte ratio

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