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Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
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A Step Toward Disentangling the Complex Relationship Between Vitamin D and Kidney Function

Alexander Teumer1,2, Casey M Rebholz3

  • 1Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.

The Journal of Clinical Endocrinology and Metabolism
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No abstract available in PubMed .

Keywords:
GWAScausal inferencechronic kidney diseasemendelian randomizationrenal functionvitamin D

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