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Dose of ibrutinib in Waldenström macroglobulinaemia: Less can be more

Ibrahim Tohidi-Esfahani1, Judith Trotman1,2

  • 1Haematology Department, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.

British Journal of Haematology
|January 30, 2023
PubMed

Ibrutinib changed the landscape of treatment in Waldenström macroglobulinaemia (WM) with excellent responses; however, there are high rates of dose reduction due to adverse events. The impact of this reduced dosing is unclear with regards to outcomes. Sarosiek and colleagues provide valuable data in a very large retrospective study demonstrating that dose reduction is effective in managing adverse events in the majority, with equivalent, if not better, outcomes than those without dose reductions.

Keywords:
Waldenstrom macroglobulinaemiabruton tyrosine kinase inhibitoribrutinib

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