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Related Concept Videos

Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

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The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
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Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

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The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
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Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Classification of Connective Tissues01:30

Classification of Connective Tissues

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The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
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Three-Compartment Open Model01:06

Three-Compartment Open Model

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The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
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Location and Orientation of the Heart01:13

Location and Orientation of the Heart

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The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
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Related Experiment Video

Updated: Aug 12, 2025

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
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[Mediastinum-new compartment classification].

Sebastian Röhrich1, Benedikt H Heidinger2, Florian Prayer2

  • 1Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, 1090, Währinger Gürtel 18-20, Wien, Österreich. sebastian.roehrich@meduniwien.ac.at.

Radiologie (Heidelberg, Germany)
|January 30, 2023
PubMed
Summary
This summary is machine-generated.

The International Thymic Malignancy Interest Group (ITMIG) developed a new 3D mediastinal classification. This standardized approach improves communication and diagnosis for mediastinal masses, replacing older, less defined divisions.

Keywords:
AnatomyParavertebral compartmentPrevascular compartmentThoracic cavityVisceral compartment

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Area of Science:

  • Radiology and Thoracic Surgery
  • Medical Imaging
  • Anatomical Classification

Context:

  • Mediastinal masses present a diverse range of conditions requiring accurate diagnosis and localization.
  • Effective interdisciplinary management is crucial for patient prognosis and treatment planning.
  • Traditional mediastinal divisions lack clear definition, potentially hindering communication.

Purpose:

  • To compare traditional mediastinal divisions with the new ITMIG classification.
  • To elucidate the advantages of the ITMIG's three-dimensional mediastinal compartmentalization.
  • To explain pathologies within the newly defined compartments.

Summary:

  • The ITMIG has introduced a novel three-dimensional classification system for the mediastinum, moving beyond traditional anterior, middle, and posterior divisions.
  • This new classification, based on cross-sectional imaging, redefines mediastinal compartments as prevascular, visceral, and paravertebral.
  • It aims to enhance diagnostic accuracy and standardize interdisciplinary communication regarding mediastinal lesions.

Impact:

  • Promotes standardization in classifying mediastinal compartments, crucial for consistent diagnosis and treatment.
  • Facilitates clearer interdisciplinary communication by providing a more precise anatomical framework.
  • Aligns mediastinal lesion classification with modern cross-sectional imaging techniques and clinical workflows.