Related Experiment Video
Updated: Aug 12, 2025
Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
Published on: June 21, 2019
miRNA dysregulation in traumatic brain injury and epilepsy: a systematic review to identify putative biomarkers for
1Department of Central Sophisticated Instrumentation Cell, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Kumarprincebt@gmail.com.
Abstract:
Traumatic brain injury (TBI) leads to post-traumatic epilepsy (PTE); hence, both TBI and PTE share various similar molecular mechanisms. MicroRNA (miRNA) is a small noncoding RNA that acts as a gene-silencing molecule. Notably, the dysregulation of miRNAs in various neurological diseases, including TBI and epilepsy, has been reported in several studies. However, studies on commonly dysregulated miRNAs and the regulation of shared pathways in both TBI and epilepsy that can identify potential biomarkers of PTE are still lacking. This systematic review covers the peer-review publications of TBI and database studies of epilepsy-dysregulated miRNAs of clinical studies. For TBI, 290 research articles were identified after screening, and 12 provided data for dysregulated miRNAs in humans. The compiled data suggest that 85 and 222 miRNAs are consecutively dysregulated in TBI and epilepsy. In both, 10 miRNAs were found to be commonly dysregulated, implying that they are potentially dysregulated miRNAs for PTE. Furthermore, the targets and involvement of each putative miRNA in different pathways were identified and evaluated. Additionally, clusters of predicted miRNAs were analyzed. Each miRNA's regulatory role was linked with apoptosis, inflammation, and cell cycle regulation pathways. Hence, these findings provide insight for future diagnostic biomarkers.
Insights
Traumatic brain injury (TBI) can cause post-traumatic epilepsy (PTE). This review identifies 10 common microRNAs (miRNAs) dysregulated in both conditions, suggesting potential biomarkers for PTE diagnosis.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Traumatic brain injury (TBI) is a known cause of post-traumatic epilepsy (PTE).
- Both TBI and PTE share overlapping molecular mechanisms.
- MicroRNA (miRNA) dysregulation is implicated in neurological disorders, including TBI and epilepsy.
Approach:
- This systematic review analyzed peer-reviewed publications on TBI and database studies on epilepsy-dysregulated miRNAs.
- Data from 12 human TBI studies identified 85 dysregulated miRNAs.
- Epilepsy studies revealed 222 dysregulated miRNAs.
Key Points:
- Ten miRNAs were commonly dysregulated in both TBI and epilepsy.
- These common miRNAs are potential biomarkers for predicting PTE.
- miRNA targets and pathways, including apoptosis, inflammation, and cell cycle regulation, were analyzed.
Conclusions:
- The identified common miRNAs offer insights into shared molecular pathways in TBI and PTE.
- These findings pave the way for developing novel diagnostic biomarkers for PTE.
- Further research into these miRNAs could elucidate their regulatory roles in neurological disease progression.
More Related Videos
07:07Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
Published on: February 10, 2020
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
