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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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The pathophysiology and management of vascular calcification in chronic kidney disease patients

Mehmet Kanbay1,2, Sidar Copur3, Cem Tanriover3

  • 1Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.

Expert Review of Cardiovascular Therapy
|January 30, 2023
PubMed

Insights

Vascular calcification (VC) in chronic kidney disease (CKD) patients causes significant health issues. This review analyzes VC pathophysiology, assessment, and treatments, highlighting the need for improved management strategies.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pathology

Background:

  • Vascular calcification (VC) is a critical comorbidity in chronic kidney disease (CKD) patients, contributing to high morbidity and mortality.
  • VC involves pathological mineral deposition in the vascular intima and media, necessitating effective treatment strategies.

Approach:

  • This review synthesizes current knowledge on VC pathophysiology in CKD.
  • It details methods for predicting and assessing VC.
  • The review covers existing and potential therapeutic interventions for VC.

Key Points:

  • Predicting, assessing, and treating VC are crucial for managing CKD patients.
  • Current therapeutic options for VC lack definitive evidence and consensus.
  • Further research is needed to improve VC detection, documentation, and treatment.

Conclusions:

  • Advances in VC research are expected in clinical management areas: prediction, assessment, and treatment.
  • Improved prediction and assessment methods are vital, alongside developing new therapeutic alternatives.
  • Future research will likely lead to targeted therapies and personalized management plans for CKD patients with VC.
Abstract

Keywords:
Vascular calcificationchronic kidney diseaseintimal calcificationtherapeutics

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