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Cortical neuronal assemblies coordinate with EEG microstate dynamics during resting wakefulness.

Richard Boyce1, Robin F Dard1, Rosa Cossart1

  • 1INMED, INSERM, Aix Marseille University, 13273 Marseille, France.

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|January 30, 2023
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Summary

Consciousness depends on coordinated brain activity, not just neuronal assembly structure. Brain-wide electrical patterns synchronize with local neuronal activity during wakefulness, but not sleep, suggesting this coordination is key for conscious experience.

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CP: NeuroscienceEEG microstatescalcium imagingconsciousnesscortical assembliesvigilance states

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Sleep Research

Background:

  • Disrupted cortical activity is linked to anesthesia-induced unconsciousness.
  • The role of cortical assembly activity in natural variations of consciousness is not well understood.

Purpose of the Study:

  • To investigate the relationship between cortical assembly activity and vigilance states (wakefulness, sleep).
  • To explore the coordination between local cortical activity and global brain dynamics across different states of consciousness.

Main Methods:

  • Vigilance state-specific clustering analysis of 2-photon calcium imaging data from the sensorimotor cortex.
  • Global electroencephalogram (EEG) microstate analysis of multi-EEG signals.

Main Results:

  • No significant differences in the structure of cortical assembly activity were found across quiet wakefulness (QW), non-rapid eye movement sleep (NREMs), and REM sleep.
  • Significant coordination between global EEG microstate dynamics and local cortical assembly activity was observed during QW, but not during sleep.
  • Reduced consciousness during NREMs and REM sleep was not associated with altered assembly structure.

Conclusions:

  • The structure of cortical assemblies alone does not explain variations in consciousness during different vigilance states.
  • Coordination between local cortical assembly activity and global brain dynamics during wakefulness may be crucial for sustained conscious experience.
  • This coordination, rather than assembly structure, might be a key factor differentiating conscious states.