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Cardiac Vagal Regulation Is Impeded in Children With Cyclic Vomiting Syndrome.
Jacek Kolacz1,2, Katja Kovacic3, Linh Dang1,4
1Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Children with cyclic vomiting syndrome (CVS) show reduced vagal regulation, indicated by lower respiratory sinus arrhythmia (RSA) and vagal efficiency (VE). This suggests autonomic dysfunction may contribute to CVS in children.
Area of Science:
- Pediatric Gastroenterology
- Autonomic Neuroscience
- Clinical Medicine
Background:
- Cyclic vomiting syndrome (CVS) pathophysiology is poorly understood, with evidence suggesting autonomic nervous system dysfunction.
- Reduced parasympathetic vagal regulation is observed in children with gut-brain interaction disorders.
Purpose of the Study:
- To investigate dynamic cardiac vagal regulation in children with CVS compared to healthy controls (HC).
Main Methods:
- Cardiac autonomic function was assessed in 31 children with CVS and 66 HC (ages 8-18) using electrocardiogram during posture challenges.
- Key variables analyzed included heart period, respiratory sinus arrhythmia (RSA), and vagal efficiency (VE).
Main Results:
- Children with CVS exhibited shorter heart period and significantly lower RSA compared to HC.
- Vagal efficiency (VE) was significantly reduced in children with CVS throughout posture changes.
Conclusions:
- Children with CVS demonstrate impaired parasympathetic autonomic regulation, even between episodes.
- Abnormal vagal modulation may play a role in CVS pathophysiology, comorbidities, and triggers.
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